Anatomy of a trip

by Vivienne Baillie Gerritsen

Sunday mornings are spent reading the news. Sometimes they're spent catching up on news. This is how, last weekend, I was sorry to learn - and so late - that the British zoologist and ethologist Desmond Morris had died. When I was young in the UK, Desmond Morris was huge. I had found his popular science books, in particular 'The Naked Ape' inspiring when I read them already twenty years after their original publication. There's a lot I wouldn't subscribe to anymore, but it was thanks to Morris that it really dawned on me that humans are animals too. We're equipped with things that have made us fundamentally different but, all in all, the way we are made follows the same guidelines as that of any animal. In the same pile of newspapers, I also read about psilocybin, the psychedelic produced by the mushroom P.semilanceata and how it seems to cause architectural changes in the brain. Still immersed in thoughts about Desmond Morris, his art immediately sprung to mind. For, yes, he was a respected surrealist artist too, and his paintings have always reminded me, in a strange sort of way, of the cellular world. The research the magic mushroom article was referring to describes a receptor psilocybin binds to in our brain, and the anatomical effects it is said to have had on several individuals. The psychedelic binds to a receptor known as 5-HT2AR, to which serotonin usually binds.

Protein Spotlight (ISSN 1424-4721) is a monthly review written by the Swiss-Prot team of the SIB Swiss Institute of Bioinformatics. Spotlight articles describe a specific protein or family of proteins on an informal tone. Follow us: Subscribe · Facebook · Linkedin

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"La vie, l'amour, la mort & les protéines" (in French only) is a wonderful and unique collection of twenty comic strips created with cartoonist aloys lolo. Each comic describes one protein taken from the Protein Spotlight articles. The album was published in November 2023 by Antipodes, Switzerland. Order your copy online. English version online here.

Snapshot : Calmodulin

Charles Darwin’s very popular theory of evolution emerged from his observation of chaffinches on the Galapagos Islands. He had recorded 14 different species, from as many different islands, when it became clear to him that, despite differences, the species were nevertheless related. The obvious disparity lay in the shape of their beaks and this was directly related to a specific diet. Chaffinches which lived on flowers and cactus fruit had long narrow beaks, while those which lived off strong-shelled grains had large, powerful beaks. What was it that could drive such differences ? It took the best part of two centuries before anyone could give an answer. And we know today, that the shape of a chaffinch’s beak is dependent on the expression of a protein: calmodulin.

A little bit of praise!

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— Rohan Chaubal, Senior Researcher in Genomics

Thank you to Emanuela Lucaci whose work we reproduce on our site!